Effects of Liandou Qingmai Recipe(连豆清脉方)on Endothelin-1, Nitric Oxide, Interleukin-6 and Interleukin

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To observe effects of Liandou Qingmai Recipe (连豆清脉方) on endothelin-1 (ET-1),nitric oxide (NO),interleukin-6 (IL-6) and IL-10 levels in patients with coronary heart disease.Methods:Total 101 cases with coronary heart disease were randomly divided into a treatment group (n=45) treated by Liandou Qingmai Recipe and a standard treatment group (control group,n=56),with a normal group of 16 health persons set up.Changes of ET-1,NO,IL-6 and IL-10 levels were measured before treatment and after treatment for two weeks.And the data were analyzed by SPSS 16.0 statistic software.Results:Before treatment,the levels of ET-1,IL-6 and IL-10 levels were significantly higher and NO was significantly lower in the patients with coronary heart disease than those in the normal group (90.7±12.7 ng/L vs 41.8±13.5 ng/L,9.17±0.18 ng/L vs 1.10±0.08 ng/L,1.94±0.26 ng/L vs 1.09±0.06 ng/L,and 92.2±17.7 μmol/L vs 124.5±27.2 μmol/L; all P<0.05),with no significant differences in the levels of ET-1,NO,IL-6 and IL-10 between the treatment group and the control group (P>0.05); After treatment,ET-1 and IL-6 significantly decreased in the treatment group and the control group,and NO increased in the treatment group; And IL-6 level was significantly lower and NO level was higher in the treatment group than those in the control group (4.48±1.22 ng/L vs 5.13±1.85 ng/L,117.4±22.3 μmol/L vs 92.4±17.1 μmol/L; both P<0.05); There was a positive correlation between IL-6 and IL-10,and a negative correlation between NO and IL-10 (r=0.142,r=-0.152; both P<0.05).Conclusion:Liandou Qingmai Recipe can decline IL-6,IL-10 and ET-1 levels,and raise NO level in patients with coronary heart disease on the basis of standard treatment,so as to inhibit endothelial inflammatory response,improve vascular endothelial function,with stronger anti-AS action; And vascular endothelial lesion is related with inflammatory response.
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