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卵巢癌(Ovarian Cancer)是妇科第二常见、死亡率最高的恶性肿瘤,多见于更年期和绝经期妇女。该病90%以上起源于卵巢表面上皮,但其病因学及发病机制目前尚不明确。有研究证实其发生、发展除与促性腺激素有关外,还与雌激素关系密切。雌激素有利于卵巢上皮肿瘤的形成,对卵巢上皮细胞具有基因转录活性调节和促进其有丝分裂的作用。卵巢上皮细胞体外实验显示,17β-雌二醇(E2)能在mRNA和蛋白水平上调白细胞介素(IL)-6基因,抑制细胞凋亡。IL-6具有促炎和抗炎的特性,在正
Ovarian Cancer is the second most common gynecological cancer with the highest mortality rate, which is more common in menopausal and postmenopausal women. More than 90% of the disease originated in the ovarian surface epithelium, but its etiology and pathogenesis is not yet clear. Studies have confirmed its occurrence and development in addition to gonadotropin-related, but also closely related with estrogen. Estrogen is beneficial to the formation of ovarian epithelial tumors, ovarian epithelial cells with gene transcriptional activity regulation and promote their mitosis. In vitro experiments of ovarian epithelial cells showed that 17β-estradiol (E2) upregulates interleukin (IL) -6 gene and inhibits apoptosis at mRNA and protein levels. IL-6 has pro-inflammatory and anti-inflammatory properties that are positive