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本文对放免分析血浆ACTH及血清皮质醇的临床应用价值作了评价。Addison病患者以高血浆ACTH及低血清皮质醇为特征,肾上腺皮质肿瘤可根据低血浆ACTH值与Cushing病鉴别。多数Cushing病患者血ACTH和皮质醇水平都升高,垂体功能减低者两种激素水平都降低。无论Cushing病或垂体功能减低者两种激素水平与正常值都有部分重叠。小剂量地塞米松抑制试验对鉴别Cushing病和单纯肥胖症很有价值。氨基导眠能试验可把垂体功能减低者和正常者区分开来。
This article evaluates the clinical value of radioimmunoassay for plasma ACTH and serum cortisol. Addison’s disease is characterized by high plasma ACTH and low serum cortisol, and adrenocortical tumors can be distinguished from Cushing’s disease based on low plasma ACTH values. Most Cushing disease patients with elevated blood ACTH and cortisol levels, hypopituitarism decreased both hormone levels. Both hormones, Cushing’s disease or hypopituitarism, partially overlap with normal levels. Low-dose dexamethasone suppression tests are valuable for identifying Cushing’s disease and simple obesity. Amino acid sleep test can reduce the pituitary dysfunction and normal people to distinguish.