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目的了解2011-2013年上海市奉贤地区输血传播HBV的窗口期残留风险及变化趋势。方法对上海市奉贤区血站2011-2013年采集的血液进行监测,选择重复献血者为研究对象,通过对7例HBs Ag-HBV DNA+标本及101份HBs Ag筛查不合格标本,进行复检、确认以及乙型肝炎病毒标志物血清学二对半检测,获得窗口期转阳数,根据重复献血者献血间隔期转阳模型,计算发病率和残留风险。结果奉贤地区2011-2013年重复献血者HBV的窗口期残留风险为1∶27 548,较2002-2005年的1∶5 950及2007-2010年的1∶13 670低。结论奉贤地区的重复献血者HBV的窗口期残留风险呈逐年下降趋势。
Objective To understand the window-period residual risks and trends of transfusion-transmitted HBV in Fengxian area, Shanghai during 2011-2013. Methods The blood collected from 2011 to 2013 in Fengxian District of Shanghai was monitored. Blood samples were collected from repeat blood donors. Seven samples of HBsAg-HBV DNA + and 101 samples of HBsAg were screened for retesting , Confirmed and hepatitis B virus markers serological two and a half test to obtain the window of the sun, according to repeated donor blood donation interval model of Yang, calculate the incidence and residual risk. Results The window-period residual risk of repeated blood donors from 2011 to 2013 in Fengxian was 1:27 548, lower than 1:5 950 in 2002-2005 and 1:13 670 in 2007-2010. Conclusion The window-period residual risk of repeated blood donors in Fengxian area is decreasing year by year.