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奥曲肽已用于静脉曲张出血的临床治疗,但有关其应用剂量的详细研究尚缺乏,奥曲肽对肝硬化患者门脉压力及侧支循环的影响尚存在争议。此研究旨在观察经静脉以不同方式输注不同剂量的奥曲肽对肝硬化门脉高压患者血流动力学的影响。 方法:此研究中共包括68例肝硬化门脉高压、食道静脉曲张患者。所以患者根据预先的方案分为4组,各组按不同的方式及严格的双盲原则给予奥曲肽或安慰剂。①静脉注射50μg奥曲肽(n=9),静脉注射500μg奥曲肽(n=
Octreotide has been used in the clinical treatment of variceal hemorrhage. However, there is still a lack of detailed studies on its application dose. The influence of octreotide on portal pressure and collateral circulation in cirrhotic patients remains controversial. The aim of this study was to investigate the effects of intravenous infusion of different doses of octreotide on hemodynamics in cirrhotic patients with portal hypertension. Methods: A total of 68 patients with portal hypertension and esophageal varices were included in this study. The patients were then divided into 4 groups according to the pre-schedule, with each group given octreotide or placebo in different ways and with a strict double-blind principle. ① intravenous injection of 50μg octreotide (n = 9), intravenous injection of 500μg octreotide (n =