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信号转导在难治性癫痫的发病机制中起着重要作用,胞外信号脑源性神经生长因子、神经递质通过跨膜结构酪氨酸受体激酶、G蛋白偶联受体;神经细胞粘附分子介导的细胞直接接触都可激活胞内蛋白激酶,如丝裂素活化蛋白激酶、蛋自激酶C,通过调节神经元生长、分化、凋亡和诱导神经元重组等方式参与难治性癫痫的发病。bcl-2基因和缝隙连接蛋白介导的细胞直接联系可调节信号转导。因此,难治性癫痫的信号转导是一多因素参与、调控的过程。
Signal transduction plays an important role in the pathogenesis of refractory epilepsy. Extracellular signal transduction of brain-derived nerve growth factor, neurotransmitter through the transmembrane tyrosine receptor kinase, G protein-coupled receptors; Adhesion molecule-mediated direct cell-cell activation activates intracellular protein kinases, such as mitogen-activated protein kinase and egg kinase K, which are involved in refractory disease by regulating neuronal growth, differentiation, apoptosis, and induction of neuronal remodeling The incidence of epilepsy. Bcl-2 gene and gap junction protein-mediated direct cellular regulation of signal transduction. Therefore, the signal transduction of refractory epilepsy is a multi-factor involved in the regulation of the process.