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近年来,口服胆石溶解剂治疗胆石症取得了一定的效果。本文仅就鹅去氧胆酸(CDCA)和熊去氧胆酸(UDCA)的作用机制、存在问题及今后研究方面等,以及最新进展,加以概述。一、CDCA 与UDCA 的作用机制现已明确,胆固醇、胆汁酸和卵磷脂都影响结石形成。超过一定比例的胆固醇在胆汁酸和卵磷脂的混合胶粒中是很不稳定的,易析出液晶或固晶。口服胆汁酸溶解剂纠正胆汁酸和胆固醇的异常状态,是溶石疗法的理论基础。但详细机理尚不明瞭,可能与下列因素有关:①胆汁酸池的扩大;②肝内胆固醇合成减
In recent years, oral cholelithiasis has achieved some results in the treatment of cholelithiasis. In this article, only the mechanism of action of chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA), existing problems and future research, as well as the latest developments are summarized. First, the mechanism of action of CDCA and UDCA It has been clear that cholesterol, bile acids and lecithin affect the formation of stones. More than a certain percentage of cholesterol in bile acids and lecithin mixture of particles is very unstable, easy to precipitate liquid crystal or solid crystal. Oral bile acid dissolving agent to correct the abnormal state of bile acids and cholesterol, is the theoretical basis of dissolution therapy. However, the detailed mechanism is not clear, and may be related to the following factors: ① expansion of bile acid pool; ② intrahepatic cholesterol synthesis minus