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目的：探讨美托洛尔对扩张型心肌病合并充血性心力衰竭（ＣＨＦ） 的血液动力学效应与应用时间关系。方法：扩张型心肌病心力衰竭病人４０ 例随机分为两组：美托洛尔治疗组２０ 例；常规治疗对照组２０ 例。两组均在治疗开始前１ ｄ、治疗１ 个月和３ 个月时作超声心动图测定左室功能，摄心脏正位片测定心胸比和心脏面积，并按ＮＹＨＡ分级评定心功能。结果：治疗组１ 个月时应用美托洛尔治疗仅使心率和血压下降，而呼吸频率和左室射血分数（ＬＶＥＦ）无明显变化。治疗３ 个月时美托洛尔组ＬＶＥＦ显著高于对照组（３７ ．３５ ±６ ．２８ ｖｓ ３３．２５±６．４６，Ｐ＜ ０．０１），美托洛尔组心胸比和心脏面积明显缩小（分别Ｐ＜ ０ ．００１）；显效患者年龄偏小，心率偏快。结论：美托洛尔治疗扩张型心肌病心力衰竭的血液动力学效应与应用时间长短有明显关系。认为美托洛尔长期治疗对此类病人是有益的。
Objective: To investigate the effect of metoprolol on the hemodynamic effect of dilated cardiomyopathy complicated with congestive heart failure (CHF) Methods: 40 cases of dilated cardiomyopathy patients with heart failure were randomly divided into two groups: metoprolol treatment group 20 cases; routine treatment control group 20 cases. Left ventricular function was measured by echocardiography at 1 day before treatment, at 1 month and at 3 months after treatment, cardiothoracic ratio and heart area were taken from the echocardiogram and NYHA classification was used to evaluate the cardiac function. Results: Metoprolol treatment only reduced heart rate and blood pressure at 1 month in treatment group, while respiratory rate and left ventricular ejection fraction (LVEF) did not change significantly. At 3 months, the LVEF in metoprolol group was significantly higher than that in control group (37.35 ± 6.28 vs 33.25 ± 6.46, P <0.01) Significantly reduced (P <0 .001 respectively); effective age of patients is small, fast heart rate. Conclusions: The hemodynamic effects of metoprolol in the treatment of dilated cardiomyopathy with heart failure have a significant relationship with the duration of application. Term treatment of metoprolol is beneficial to such patients.