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目的分析南阳市2008-2014年疑似预防接种异常反应(AEFI)发生和报告情况,评价预防接种的安全性。方法通过中国免疫规划监测信息管理系统和AEFI信息管理系统,收集南阳市常规免疫接种数据和AEFI个案数据,采用描述流行病学分析。结果南阳市2008-2014年监测系统共报告741例AEFI,每100万剂发生率为27.39%;46.42%分布在西峡县、桐柏县和方城县;79.08%个案发生在接种后48 h内;61.13%AEFI分布在5~9月份;72.88%为≤1岁儿童;93.39%为一般反应,发生率为25.58/100万剂;报告发生率居前三位的一类疫苗是麻腮风(61.60/100万)、白破(60.37/100万)和无细胞百白破(58.17/100万)。结论南阳市部分地区AEFI监测敏感性需提高,国家免疫规划疫苗安全性较好。
Objective To analyze the incidence and reporting of suspected immunization anomalies (AEFI) in Nanyang from 2008 to 2014 and evaluate the safety of vaccination. Methods The routine immunization data and AEFI data of Nanyang were collected through the China Immunization Program Monitoring Information Management System and AEFI Information Management System, and the descriptive epidemiological analysis was used. Results A total of 741 cases of AEFI were reported in Nanyang from 2008 to 2014, with a rate of 27.39% for every 1 million doses. 46.42% were distributed in Xixia County, Tongbai County and Fangcheng County and 79.08% occurred in 48 hours after inoculation ; 61.13% AEFI distribution in the May to September; 72.88% ≤1 year-old children; 93.39% for the general reaction, the incidence was 25.58 / 1 million doses; the top three reported incidence of a vaccine is MMR (61.60 / 100 million), white broken (60.37 / 100 million) and cell-free diphtheria (58.17 / 100 million). Conclusion The sensitivity of AEFI surveillance in some areas of Nanyang needs to be improved, and the vaccine of the national immunization program is safe.