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目的:探讨左旋咪唑(Levamisole,LMS)对实验性变态反应性脑脊髓炎(experimentalallergicencephalomyelitis,EAE)大鼠脊髓内单个核细胞上CD28和CD4表达的影响及其意义。方法:采用流式细胞术检测EAE大鼠脊髓单个核细胞上CD28和CD4的表达水平。结果:LMS同时给药组和预处理的EAE组大鼠脊髓内单个核细胞上CD28和CD4的表达水平,均明显高于非LMS处理的EAE模型组。结论:LMS能促进EAE大鼠脊髓内单个核细胞上CD28和CD4的表达,这可能是LMS诱发的炎性脱髓鞘白质脑病发病机制中的一个重要环节。
Objective: To investigate the effect and significance of levamisole (LMS) on the expression of CD28 and CD4 on mononuclear cells of spinal cord in rats with experimental allergic encephalomyelitis (EAE). Methods: The expression of CD28 and CD4 in spinal cord mononuclear cells of EAE rats was detected by flow cytometry. Results: The expression of CD28 and CD4 in mononuclear cells of spinal cord in LMS administration group and pretreated EAE group were significantly higher than those in non-LMS treated EAE model group. CONCLUSION: LMS can promote the expression of CD28 and CD4 on mononuclear cells in spinal cord of EAE rats, which may be an important link in the pathogenesis of inflammatory demyelinating leukoencephalopathy induced by LMS.