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目的探讨引起系统性红斑狼疮(SLE)患者伴发感染的易感因素,为临床防治SLE患者伴发感染提供理论依据。方法收集2005年1月-2012年10月本科住院的427例SLE患者,通过单因素和多因素Logistic回归方法对伴发感染的SLE患者的临床资料等进行分析。结果 SLE患者伴发感染发生率为51.52%(220/427);易感因素主要有补体缺陷和免疫异常、年龄、病情活动、合并有基础性疾病、长期大剂量糖皮质激素治疗等。年龄、应用广谱抗生素、激素冲击治疗、住院时间延长、病情活动性与感染的发生密切相关(P<0.05)。结论 SLE患者易伴发感染,这也是导致患者多脏器功能衰竭甚至死亡的重要原因。补体缺陷和免疫异常、病情活动、合并有基础疾病、特殊治疗方法及不合理应用抗生素是伴发感染的独立危险因素。
Objective To investigate the susceptibility factors of systemic lupus erythematosus (SLE) patients with infection and provide a theoretical basis for prevention and treatment of SLE patients with concomitant infection. Methods A total of 427 SLE patients admitted to our hospital from January 2005 to October 2012 were enrolled in this study. The clinical data of SLE patients with infection were analyzed by single factor and multivariate Logistic regression. Results The incidence of concomitant infection in SLE patients was 51.52% (220/427). The predisposing factors were mainly complement defect and immunodeficiency, age, disease activity, combined with underlying diseases, and long-term high-dose glucocorticoid therapy. Age, the use of broad-spectrum antibiotics, hormone therapy, prolonged hospital stay, disease activity and infection are closely related (P <0.05). Conclusion Patients with SLE are predisposed to infection, which is also an important reason for multiple organ failure and even death in patients. Complement defects and immune disorders, disease activity, with underlying diseases, special treatment methods and unreasonable use of antibiotics is an independent risk factor associated with infection.