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应用ＬＳＡＢ免疫组织化学方法研究ｎｍ２３、ＥＲ和ＰＲ在５０例喉癌的表达变化与喉癌生物学行为及淋巴结转移的关系。结果发现ｎｍ２３、ＥＲ和ＰＲ表达与肿瘤大小、浸润深度、淋巴结转移和复发显著相关Ｐ＜０．０１或Ｐ＜０．０５）。ｎｍ２３低表达者淋巴结转移率（９０．６３％），高于正常表达者（１６．６７％，Ｐ＜０．０１），ｎｍ２３低表达与肿瘤的组织学分级相关（Ｐ＜０．０５）。同时发现，ＥＲ表达与癌细胞增殖活性显著相关。ＥＲ阴性者淋巴结转移率（８０％）高于ＥＲ阳性者（４０％，Ｐ＜０．０５）。ＰＲ阴性者淋巴结转移率（７８．５７％）高于ＰＲ阳性者（４５．４５％，Ｐ＜０．０５）。ｎｍ２３、ＥＲ和ＰＲ在喉癌淋巴结转移中的关系为独立的联合作用，提示ｎｍ２３、ＥＲ和ＰＲ表达变化在喉癌浸润、增殖、淋巴结转移及复发中起重要作用。
LSAB immunohistochemistry was used to study the relationship between the expression of nm23, ER and PR in 50 cases of laryngeal cancer and the biological behavior and lymph node metastasis of laryngeal cancer. The results showed that nm23, ER and PR expressions were significantly associated with tumor size, depth of invasion, lymph node metastasis and recurrence (P <0.01 or P <0.05). The rate of lymph node metastasis (90.63%) in nm23 low expression group was higher than that in normal expression group (16.67%, P <0.01). The low expression of nm23 was correlated with tumor grade (P <0.05). At the same time, it was found that the expression of ER was significantly correlated with the proliferation activity of cancer cells. The rate of lymph node metastasis (80%) in ER-negative patients was higher than that in ER-positive patients (40%, P <0.05). PR-negative lymph node metastasis rate (78.57%) was higher than PR-positive (45.45%, P <0.05). The relationship between nm23, ER and PR in lymph node metastasis of laryngeal carcinoma was independent, suggesting that the expression of nm23, ER and PR plays an important role in the invasion, proliferation, lymph node metastasis and recurrence of laryngeal carcinoma.