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目的了解全细胞百白破联合疫苗(简称wDTP)接种反应的发生情况,更好地评价疫苗的安全性,为今后免疫策略的调整提供依据。方法接种疫苗后1个月内按自制的预防接种异常反应记录表调查。结果局部反应发生率为13.33%,各针次之间的局部反应差异无统计学意义(H=3.60,P>0.05);发热反应发生率为11.32%,各针次间发热反应差异有统计学意义(H=6.61,P<0.05)。结论应严格掌握疫苗接种禁忌症和接种注意事项,尽量减少wDTP接种反应发生,随着扩大免疫规划的实施,逐步推广使用更安全有效的无细胞百白破联合疫苗。
OBJECTIVE: To understand the occurrence of vaccination response of whole-cell diphtheria-pestti combined vaccine (wDTP), to better evaluate the safety of vaccine and to provide basis for the future adjustment of immunization strategy. Methods Vaccination within 1 month after vaccination according to homemade record of abnormal reaction records. Results The incidence of local reactions was 13.33%. There was no significant difference in the local reactions between the needles (H = 3.60, P> 0.05). The incidence of fever was 11.32% Significance (H = 6.61, P <0.05). Conclusions Vaccination contraindications and vaccination precautions should be strictly controlled to minimize the occurrence of wDTP vaccination reactions. With the implementation of the expanded immunization program, a safer and more effective cell-free diphtheria-associated vaccine will be gradually introduced.