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大量研究发现凝血因子ⅡG20210A突变与布加综合征和门静脉血栓形成有关。介绍了凝血因子Ⅱ及凝血因子ⅡG20210A突变,回顾了有关凝血因子ⅡG20210A突变对血栓形成的影响,并对凝血因子ⅡG20210A突变的患病率进行了分析,着重总结了凝血因子ⅡG20210A突变与门静脉血栓和布加综合征的关系。认为凝血因子ⅡG20210A突变在一定程度上增加了门静脉血栓和布加综合征的风险。但凝血因子ⅡG20210A突变在中国患者中的患病率极低,其也许并不足以作为中国门静脉血栓和布加综合征的病因。
A large number of studies have found that coagulation factor G20210A mutation associated with Budd-Chiari syndrome and portal vein thrombosis. Introduced the coagulation factor Ⅱ and coagulation factor Ⅱ G20210A mutation, reviewed the impact of coagulation factor Ⅱ G20210A mutation on thrombosis, and analyzed the prevalence of coagulation factor Ⅱ G20210A mutation, focusing on the coagulation factor Ⅱ G20210A mutation and portal vein thrombosis and Buddhism The relationship between the syndrome. It is believed that the mutation of G20210A may increase the risk of portal vein thrombosis and Budd-Chiari syndrome to a certain extent. However, the prevalence of clotting factor II G20210A mutation in Chinese patients is extremely low, which may not be sufficient as a cause of portal vein thrombosis and Budd-Chiari syndrome in China.