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舍格林氏综合征(Sjgren′s Syndrome简称SS)可表现口腔干燥、干燥性角结膜炎和类风湿性关节炎,凡具有以上两项即可诊断本征。临床上,干燥性角结膜炎和类风湿性关节炎都容易诊断。然而,口腔干燥是病人的主观症状,可由多种原因引起,尽管已知在SS中,口干为涎腺受累所致,但目前还无较为满意的检查方法确定SS病人涎腺受累情况。近年来,国外学者研究了SS病人涎液化学成分,提出以涎液分析作为SS的一种简单而有效的诊断措施。本文试就有关问题作一简要的综述。涎液流率的测定各研究者对SS病人涎液流率的测定结果不一,可能由于收集涎液方法不同所致,但各组资料和正常对照组比较,显示SS病人涎液流率均明显下降(表Ⅰ)。
Sjgren’s Syndrome (SS for short) can express dry mouth, keratoconjunctivitis sicca and rheumatoid arthritis. Those who have the above two items can diagnose the symptoms. Clinically, keratoconjunctivitis sicca and rheumatoid arthritis are easily diagnosed. However, oral dryness is a subjective symptom of the patient and can be caused by a variety of reasons. Although it is known that dry mouth is caused by involvement of parotid glands in SS, there is no satisfactory examination method to determine the involvement of parotid glands in SS patients. In recent years, foreign scholars have studied the chemical composition of sputum from patients with SS, and proposed a simple and effective diagnostic measure of sputum analysis as SS. This article tries to give a brief overview of relevant issues. Determination of sputum flow rate The results of sputum flow measurement in SS patients were varied among investigators. They may be due to different methods for collecting sputum, but compared with the normal control group, the sputum flow rate in SS patients was similar. A significant drop (Table I).