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目的探讨颅脑外伤患者早期血清超敏C反应蛋白(hs-CRP)与伤后抑郁的相关性分析。方法选取2012年4月至2015年4月我院收治的185例颅脑外伤患者为研究对象,检测所有患者入院时、入院12h、入院24h的血清hs-CRP水平,记录患者相关临床资料,按照伤后是否出现抑郁将患者分为抑郁组(n=48例)和非抑郁组(n=137例),比较两组患者相关临床资料的差异。结果 185例颅脑损伤患者中出现伤后抑郁的有48例(发病率25.9%);抑郁组中患者入院时格拉斯哥昏迷评分(GCS)低于非抑郁组(P<0.05)、低氧血症的比例高于非抑郁组(P<0.05);抑郁组中患者入院12h、24h的血清hs-CRP水平高于非抑郁组(P<0.05);回归分析提示入院12h的血清hs-CRP(OR=1.887,P<0.05)、和24h的血清hs-CRP(OR=1.452,P<0.05)是颅脑损伤患者中出现伤后抑郁的独立危险因素。结论血清hs-CRP与颅脑外伤后抑郁的发生具有一定的相关性,早期检测血清hs-CRP水平对于评估伤后抑郁的发生具有一定的临床意义。
Objective To investigate the correlation between early serum hs-CRP and post-traumatic depression in patients with traumatic brain injury. Methods From April 2012 to April 2015, 185 cases of craniocerebral trauma admitted in our hospital were selected as the research object. The serum hs-CRP levels of all patients admitted to hospital at admission for 12 hours and admitted to hospital for 24 hours were recorded. The clinical data of patients were recorded. Patients with depression were divided into depression group (n = 48) and non-depression group (n = 137). The differences of clinical data between the two groups were compared. Results There were 48 cases of post-traumatic depression (incidence rate 25.9%) in 185 traumatic brain injury patients. The GCS of depression group was lower than that of non-depression group (P <0.05), hypoxemia (P <0.05). The level of serum hs-CRP in depression group was higher than that in non-depression group at 12h and 24h (P <0.05). The regression analysis indicated that the serum hs-CRP = 1.887, P <0.05), and serum hs-CRP at 24 h (OR = 1.452, P <0.05) was an independent risk factor for post-traumatic depression in patients with craniocerebral injury. Conclusion Serum hs-CRP has some correlation with the occurrence of depression after traumatic brain injury. Early detection of serum hs-CRP levels has some clinical significance for the assessment of post-traumatic depression.