遗传性掌跖角化症(Rerataderma Falm oplanlare heredntaria)又称弥漫性掌跖角化症或Thost-Unna综合症,是一种以掌跖皮肤过度角化为特征的常染色体显性遗传性疾病。现就其家系调查报告如下: 一、病例:吴××(先证者),女性,65岁,农民。自述从记事起双手掌和跖面皮肤逐渐变粗、变硬,开始无明显症状,以后,上述表现日渐加重,皲裂呈龟甲样裂痕,尤以冬季为甚,休息或涂擦药膏后好转。查体:营养发育中等,毛发牙齿正常,颈软, Hereditary palmoplantar disease (Rerataderma Falm oplanlare heredntaria), also known as diffuse palmoplantar keratosis or Thost-Unna syndrome, is a plantar plantar hyperkeratosis characterized by autosomal dominant genetic disease. Now on the investigation of their families are as follows: First, the case: Wu × × (proband), female, 65 years old, farmer. Readme from the notes from the palms and plantar skin gradually thicken and harden, no obvious symptoms began, after the above performance is aggravating, chapped Turtle Turtle like cracks, especially in winter is very good, resting or rub ointment improved. Physical examination: medium development of nutrition, hair, normal teeth, neck soft,