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Smither(1959)根据重症肌无力病人胸腺和甲状腺炎病人的甲状腺组组学相类似,首先提出本病可能是一种自身免疫病.Nastuk等(1959,1960)首先为重症肌无力的免疫异常提供了实验室证据,发现病人血清中补体异常;Strauss等(1960)报告病人血清中有能在体外与骨骼肌抗元结合的抗体存在.同期,Simpson(1960)分析了大组重
Smither (1959) first proposed that this disease may be an autoimmune disease based on a similar thyroid glandology in thymic and thyroiditis patients with myasthenia gravis. Nastuk et al. (1959, 1960) first provided for myasthenia gravis Laboratory evidence showed abnormalities of complement in patients’ sera; Strauss et al. (1960) reported presence of antibodies in the patient’s serum that could bind to skeletal muscle antigens in vitro. Simultaneously, Simpson (1960)