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由于麻风患者在体温较低的部位如鼻子、手指等处病变严重,故有人推测麻风菌可能适宜于低温环境下生长。选用犰狳作麻风菌接种试验的原因之一是它的体温较低,只有30～35℃,只相当于人体温度较低部位的温度。作者推测犰狳由于体温较低抑制代谢活力及细胞免疫反应,有利于建立麻风菌感染。为了考核这一假设,作者以麻风菌素或植物血凝素(简称PHA)为分裂原,探讨培养温度对犰狳或人淋巴细胞变形反应的影响,而淋巴细胞变形反应是反映机体细胞免疫反应的一项重要指标。根据淋巴细胞培养72小时后摄取~3H-胸腺嘧啶核苷的数量(单位是c.p.m.)判断其变形程度。结果发现当
As leprosy patients in the lower body temperature parts such as nose, fingers and other serious disease, it was speculated that leprosy may be suitable for low temperature growth. One of the reasons why Armadillosum is used as a test for the inoculation of the leprosy is that it has a low body temperature of 30-35 ° C and corresponds only to the temperature of the lower body temperature. The authors hypothesized that armadillosium, as a result of lower body temperature, inhibited metabolic activity and cellular immune responses, favoring the establishment of a leprosy infection. In order to assess this hypothesis, the author of leprosy or phytohemagglutinin (referred to as PHA) as a split to explore the culture temperature on armadillo or human lymphocyte deformation response, and lymphocyte deformity response is to reflect the body’s cellular immune response An important indicator The degree of deformation was judged on the basis of the amount of ~ 3H-thymidine uptake in 72 hours after lymphocyte culture in c.p.m. The results found when