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甲状腺功能亢进(甲亢)患者的空腹及餐后胰岛素原(PI)水平较正常人明显升高,经抗甲状腺药物治疗后,绝大多数患者的PI水平可恢复正常。升高的PI或PI/胰岛素(INS)被认为是胰岛β细胞功能受损的早期指标,也是造成甲亢患者糖代谢紊乱的原因之一。甲亢时高甲状腺素水平、高代谢状态及各种原因造成的糖代谢紊乱是PI、PI/INS升高的原因。
Fasting and postprandial proinsulin (PI) levels in patients with hyperthyroidism (Hyperthyroidism) were significantly higher than those in normal subjects. After treatment with antithyroid drugs, PI levels in most patients returned to normal. Elevated PI or PI / insulin (INS) is considered as an early marker of impaired pancreatic beta-cell function and is also responsible for the disorder of glucose metabolism in patients with hyperthyroidism. Hyperthyroidism, high thyroxine levels, high metabolic status and various causes of glucose metabolism disorders PI, PI / INS causes.