【摘 要】
：
Drug addiction is a chronic,relapsing brain disorder.Multiple neural networks in the brain including the reward system (e.g.,the mesocorticolimbic system),the a
【机 构】
：
Department of Pharmacology and Toxicology, University at Buffalo, The State University of New York,
论文部分内容阅读
Drug addiction is a chronic,relapsing brain disorder.Multiple neural networks in the brain including the reward system (e.g.,the mesocorticolimbic system),the anti-reward/stress system (e.g.,the extended amygdala),and the central immune system,are involved in the development of drug addiction and relapse after withdrawal from drugs of abuse.Preclinical and clinical studies have demonstrated that it is promising to control drug addiction by pharmacologically targeting the addiction-related systems in the brain.Here we review the pharmacological targets within the dopamine system,glutamate system,trace amine system,antireward system,and central immune system,which are of clinical interests.Furthermore,we discuss other potential therapies,e.g.,brain stimulation,behavioral treatments,and therapeutic gene modulation,which could be effective to treat drug addiction.We conclude that,although drug addiction is a complex disorder that involves complicated neural mechanisms and psychological processes,this mental disorder is treatable and may be curable by therapies such as gene modulation in the future.
其他文献
以就业为导向,突出职业性、强化实用性是高职院校普遍强调的办学理念。本文从当前智能建筑快速发展的大形势出发,对建设多功能实训中心所实现的功能、主要设计思路、实训和管
Olfactory bulb,as one of sensory organs opening to the outside,is susceptible to toxic environment and easy to deteriorate.Recent studies in Parkinson’s diseas
Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults.Several interrelated molecula
我区第一个高产香稻品种培育成功我院教授胡子诚经过７年努力培育出宁夏第一个香稻品种，１９９４年１月２５日通过区级鉴定，并定名为“宁夏香稻１号”据专家认定，该品种一般亩产在５ｄ０至５５０公斤，最高亩产可
The polycomb repressive complexes 2 (PRC2) complex catalyzes tri-methylation of histone H3 lysine 27 (H3K27),a repressive chromatin marker associated with gene
Human genetic and pharmacological studies have demonstrated that voltage-gated sodium channels (VGSCs) are promising therapeutic targets for the treatment of pa
动植物和人类的很多重要性状都是抗性性状,这类性状大多由多基因控制且表型易受环境条件影响而发生变异的一类性状,其表型值经常呈现数量变异。但是,这类表型通常采用分级的离散有序的数量来度量。对这类抗性性状基因座(resistance trait locus, RTL)进行定位,有助于动植物抗性性状的遗传改良。然而,由于抗性性状表型观测值信息有限,增加了抗性性状遗传研究的难度,尤其是品种群体抗性性状基因座
木薯(Manihot esculenta Crantz)是一种富含淀粉的块根作物,原产南美洲亚马逊河盆地,是世界热带亚热带地区重要的粮食与经济作物之一。淀粉的合成及积累是由植物体内一系列相关酶催化下完成的。研究木薯淀粉合成过程中蔗糖代谢相关酶和淀粉合成相关酶的动态变化,探讨淀粉体发育及淀粉积累特性,对高淀粉木薯新品种的选育具有非常主要的意义。本研究以华南124木薯(SC124)品种为材料,探讨了影