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目的:采用13N-NH3 PET/CT正电子发射体层扫描技术评价葱白提取物对猪缺血再灌注心肌血流灌注的影响。方法:将24只DIV系猪随机分为假手术组、空白模型组、曲美他嗪组和葱白提取物组,每组6只。通过球囊封堵冠状动脉制备缺血再灌注模型,造模后第4天,葱白提取物组用葱白提取物灌胃(5.93mg/kg,2次/d),曲美他嗪组灌胃曲美他嗪(20mg/kg,2次/d),其他2组给同体积生理盐水,连续给药28d。各组于最后1次给药后1h行13N-NH3心肌显像检测,采用4分法评价相应节段心肌血流灌注。结果:葱白提取物与曲美他嗪均可改善缺血再灌注心肌血流灌注而保护心肌细胞,与空白模型组比较,差异有统计学意义(P<0.01);葱白提取物组与曲美他嗪组比较,差异无统计学意义(P>0.05)。结论:葱白提取物可以改善猪缺血再灌注心肌血流灌注。
OBJECTIVE: To evaluate the effect of extract of Allium scopariae on myocardial perfusion of porcine ischaemia and reperfusion using 13N-NH3 PET / CT positron emission tomography. Methods: Twenty-four DIV pigs were randomly divided into sham operation group, blank model group, trimetazidine group and light blue extract group, with 6 rats in each group. The model of ischemia / reperfusion was established by balloon occlusion of coronary arteries. On the 4th day after model establishment, the extract of Allium scopariae was gavaged with the extract of Scutellaria barbata (5.93mg / kg, twice / d) Trimetazidine (20mg / kg, 2 times / d), the other two groups were given the same volume of saline, continuous administration of 28d. The rats in each group were examined with 13N-NH3 myocardial imaging 1h after the last administration, and the corresponding segmental myocardial perfusion was evaluated by 4-point method. Results: Both light blue extract and trimetazidine could improve the myocardial perfusion of ischemia-reperfusion myocardium, which was significantly different from the blank group (P <0.01) Tharazine group, the difference was not statistically significant (P> 0.05). Conclusion: Allium extract can improve myocardial perfusion in pigs after ischemia - reperfusion.