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８名健康受试者一次口服盐酸林可霉素的口服液和片剂两种剂型后，用高效液相－电化学（ＨＰＬＣ－ＥＤ）法测定盐酸林可霉素的血药浓度，其血药浓度符合一室模型。结果盐酸林可霉素口服液和片剂主要药动学参数分别为：Ｃ_(ｍａｘ)：５．０±０．５ｍｇ／Ｌ和４．３±０．６ｍｇ／Ｌ；Ｔｍａｘ：２．１６±０．２１ｈ和２．３±０．６ｈ；ＡＵＣ：３７±７（ｍｇ·ｈ）／Ｌ和３６±７（ｍｇ·ｈ）／Ｌ。盐酸林可霉素口服液对片剂的相对生物利用度为１０４±５％，可认为口服液与片剂生物等效。
Eight healthy volunteers once oral lincomycin hydrochloride oral and tablet formulations, using high performance liquid chromatography - electrochemical (HPLC-ED) method for determination of lincomycin hydrochloride blood concentration, the blood Drug concentration in line with one-compartment model. Results The main pharmacokinetic parameters of lincomycin hydrochloride oral solution and tablets were C max 5.0 ± 0.5 mg / L and 4.3 ± 0.6 mg / L, Tmax 2.16 ± 0.21 h and 2.3 ± 0.6 h; AUC: 37 ± 7 (mg · h) / L and 36 ± 7 (mg · h) / L. The relative bioavailability of lincomycin hydrochloride oral solution to the tablets is 104 ± 5%, which is believed to be bioequivalent to the tablets.