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目的探讨血清CA199水平在肝硬化及肝癌中的临床意义。方法检测70例肝硬化患者、52例肝癌患者、40例健康人血清CA199水平并进行比较。结果肝硬化患者血清CA199水平明显高于正常对照组,并随肝硬化进展而升高(P<0.01);肝癌患者血清CA199水平明显高于肝硬化组(P<0.05)。结论肝硬化患者血清CA199水平与肝功能损害程度密切相关,可以被认为是反映肝硬化程度的一项敏感指标,对肝硬化的预后估计具有较高的参考价值,且对肝癌的诊断有重要意义。
Objective To investigate the clinical significance of serum CA199 in cirrhosis and liver cancer. Methods The serum levels of CA199 in 70 patients with liver cirrhosis, 52 patients with liver cancer and 40 healthy people were detected and compared. Results The serum level of CA199 in patients with liver cirrhosis was significantly higher than that in normal controls and increased with the progression of liver cirrhosis (P <0.01). The serum CA199 level in patients with liver cancer was significantly higher than that in cirrhosis patients (P <0.05). Conclusions Serum CA199 level in patients with cirrhosis is closely related to the degree of liver damage, which can be considered as a sensitive index to reflect the degree of cirrhosis. It has a high reference value for estimating the prognosis of liver cirrhosis and is of great significance for the diagnosis of liver cancer .