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GABA能系统对代偿已失调的大脑血液动力学起着重要作用,它还调节身体空间定位机制和前庭稳定性形成机制。研究GABA衍生物对前庭紊乱的作用是运动病有效药物研制工作的一个重要方面。作者选用吡乙酰胺(piracetam)和β-苯基GABA(phenibut)研究其对晕动时大脑供血和氧分压(pO_2)的影响。给安静状态下的家兔注射吡乙酰胺500mg/kg,能引起皮层受检部位,首先是额和枕区血流量的规律性减少;皮层枕区首先出现pO_2降低,依次为颞区,而额区变化不规律。50mg/kg也引起类似变化,但程度较轻。β-苯基GABA50mg/kg可使皮层局部血流量和大脑总血流量均减少,以颞区和额区为先,还可见颞区,其次是杜区的pO_2降低,但额区在用药后5min出现pO_2增高,继而
The GABAergic system plays an important role in compensating the dysfunctional brain hemodynamics, and it also regulates the formation of the body’s spatial localization and vestibular stability. Studying the effect of GABA derivatives on vestibular disorders is an important aspect of the development of an effective drug for motion sickness. The authors selected piracetam and β-phenyl GABA (phenibut) to study its effects on cerebral blood supply and partial pressure of oxygen (pO2) during the period of motion sickness. To the quiet state of rabbits injections of pyridinamide 500mg / kg, can cause cortical examination of the site, first of all, and forehead and occipital blood flow decreased regularly; cortical occipital first pO_2 decreased, followed by the temporal area, while the amount District irregular change. 50 mg / kg also caused similar changes, but to a lesser extent. β-phenyl GABA50mg / kg can make the cortical blood flow and cerebral blood flow were reduced to the frontal and frontal area first, also visible in the temporal area, followed by Du area of pO_2 decreased, but the amount of area after 5min Appear pO_2 increased, then