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目的观察17aα-D-高炔雌二醇-3-乙酯及联合137Csγ射线对白血病L1210的抑制作用。方法通过肿瘤细胞悬液接种法,制备IRM-1小鼠L1210白血病动物模型,实验分对照组、单放组、17aα-D-高炔雌二醇-3-乙酯(低、中、高)药物组及药物合用照射组,采用腹腔注射给药法,连续7d,1次/d,末次给药第5天处死动物,分别检测肿瘤抑制率、骨髓有核细胞数、胸腺与脾重指数指标,比较各组间的差别。结果 17aα-D-高炔雌二醇-3-乙酯各组瘤重明显小于对照组,合用照射组对荷瘤小鼠L1210白血病有较强抑制作用。结论 17aα-D-高炔雌二醇-3-乙酯对L1210白血病有明显的抑瘤作用及保护小鼠的免疫器官的作用,与γ射线合用时,能提高抑瘤疗效。
Objective To observe the inhibitory effect of 17aα-D-homovinyl-estradiol-3-ethyl ester and 137Csγ-rays on L1210 leukemia. Methods The animal model of L1210 leukemia in IRM-1 mice was established by tumor cell suspension inoculation. The experimental groups were divided into control group, radix salviae miltiorrhizae group, 17aα-D-ethinyl estradiol-3-ethyl ester The animals were sacrificed on the 5th day after the last administration for 7d and 1d, respectively. The tumor inhibition rate, number of bone marrow nucleated cells, index of thymus and spleen mass index , To compare the differences between the various groups. Results The tumor weight of 17aα-D-high-ethinyl estradiol-3-ethyl ester group was significantly smaller than that of the control group. Combination irradiation group had a strong inhibitory effect on tumor-bearing mice L1210 leukemia. Conclusion 17aα-D-high-ethinyl estradiol-3-ethyl ester has obvious anti-tumor effect on L1210 leukemia and protection of immune organs in mice. Combined with γ-rays, 17aα-D-