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对１０例原发性醛固酮腺瘤、１０例嗜铬细胞瘤、１０例Ｃｕｓｈｉｎｇ综合征肾上腺皮质腺瘤及肾上腺皮质增生组织进行内皮素－１免疫组织化学研究，结果显示内皮素－１在３种肿瘤中均呈弱、中度阳性，表明这些肿瘤组织中存在内皮素。醛固酮瘤组织中可能存在内皮素－１受体的降调节作用，嗜铬细胞瘤中的内皮素－１可能起儿茶酚胺的旁分泌作用。
An endothelin-1 immunohistochemical study of 10 cases of primary aldosterone adenoma, 10 cases of pheochromocytoma, 10 cases of adrenocortical adenoma and adrenocortical hyperplasia of Cushing syndrome showed that endothelin-1 was present in 3 The tumors were both weak and moderately positive, suggesting the presence of endothelin in these tumor tissues. There may be a down-regulation of endothelin-1 receptor in aldosteronoma tissue, and endothelin-1 in pheochromocytoma may play a paracrine role in catecholamines.