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目的探究Ivor-Lewis手术治疗胸段食管鳞癌疗效及其影响预后的因素。方法研究对象为2008年1月—2010年12月就诊的102例胸段食管鳞癌患者,患者均接受Ivor-Lewis手术治疗,采用自编问卷收集患者的临床资料,计量资料采用t检验,计数资料采用χ2检验,采用二分类Logistic回归分析方法分析患者临床资料以找出影响Ivor-Lewis手术治疗胸段食管鳞癌效果及其预后的因素,P<0.05为差异有统计学意义。结果对患者进行为期3年的随访,在本研究入组的102例患者中,54例尚存活,3年生存率为52.94%。多因素Logistic回归分析显示,淋巴结转移个数、基础疾病种数和癌细胞分化程度是影响食管鳞癌预后的危险因素。结论 Ivor-Lewis手术治疗胸段食管鳞癌患者临床疗效确切,在临床工作中,做到早发现早治疗,积极治疗基础疾病,加强体育锻炼,增加患者免疫力,改善患者的预后。
Objective To investigate the efficacy of Ivor-Lewis in the treatment of thoracic esophageal squamous cell carcinoma and its prognostic factors. Methods Totally 102 patients with thoracic esophageal squamous cell carcinoma who were treated from January 2008 to December 2010 were enrolled in this study. The patients were treated with Ivor-Lewis. The clinical data of patients were collected by self-made questionnaire. The measurement data were analyzed by t test. The data were analyzed by χ2 test, and the clinical data were analyzed by binary Logistic regression to find out the factors influencing the effect and prognosis of esophageal squamous cell carcinoma of thoracic esophagus in Ivor-Lewis surgery. The difference was statistically significant (P <0.05). Results The patients were followed up for 3 years. Of the 102 patients enrolled in this study, 54 survived and the 3-year survival rate was 52.94%. Multivariate Logistic regression analysis showed that the number of lymph node metastasis, the number of underlying diseases and the degree of differentiation of cancer cells are risk factors affecting the prognosis of esophageal squamous cell carcinoma. Conclusion Ivor-Lewis surgical treatment of thoracic esophageal squamous cell carcinoma clinical efficacy is exact, in clinical work, so early detection and early treatment, active treatment of underlying diseases, and enhance physical activity, increase patient immunity and improve patient prognosis.