The Y2O3 crucibles were introduced in the study as an altative to the traditional ceramic ones in vacuum induction melting of multi-component Nb-16Si-22Ti-2Al-2Hf-17Cr (at.%) alloys, to reveal the possible interactions between the alloy melt and the refractory crucible. Multiple melting time lengths and two cooling schemes were designed and used for the experiments. The chemical composition and microstructure of the tested alloy and the melt-crucible interaction were investigated and evaluated. In the experiments, Y2O3 crucible displays good physical-chemical compatibility. The results indicate that the increment of O element in the as-cast ingot is 0.03at.%-0.04at.% (72-97 ppm) and the increment of Y element is very insignificant. The key features of the alloy melt interacting with Y2O3 ceramics are analyzed and concluded in the paper. As a result of the dissolution reaction xY2O3 (in molten alloy) + (1-x)HfO2 (impurity) →Hf1-x Y2x O2-x, a continuous double-layer solid film consisted of HfO2 solid solution (～2 pm) and pure RfO2 (～5 pm) is formed on the surface of the test ingot after cooled down in the crucible. The experimental results show that the Y2O3 crucible is applicable to the vacuum induction melting of NbSi based alloys.