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固有免疫系统是宿主抵御病毒入侵的第一道防线.Ⅰ型干扰素是关键的抗病毒细胞因子,它在细胞建立抗病毒状态的过程中发挥了核心的作用.Ⅰ型干扰素的诱导表达是固有免疫的重要调节与效应机制.已有的研究表明:多种转录因子(NF-kappa B、ATF-2/c-Jun、IRF3、IRF7)通过在Ⅰ型干扰素的转录调控区形成稳定的转录增强复合物(enhanceosome),迅速并大量地诱导Ⅰ型干扰素表达.体内与体外的生物学分析已确立,干扰素调控因子3(IRF3)是介导细胞表达Ⅰ型干扰素最关键的转录因子,其转录活力与生物学功能直接影响细胞的抗病毒的能力.近年来,IRF3相关的细胞信号转导与调控机制等研究取得重大进展.围绕IRF3的结构、功能以及分子调控机制等方面,概述相关的研究进展,并做前沿展望。
The innate immune system is the host’s first line of defense against virus invasion. Type I interferons are the key antiviral cytokines that play a central role in establishing an antiviral state of the cell. Inducible expression of type I interferons Previous studies have shown that a variety of transcription factors (NF-kappa B, ATF-2 / c-Jun, IRF3 and IRF7) can form a stable Transcriptional enhancers rapidly and largely induce the expression of type I interferons In vivo and in vitro biological assays have established that interferon regulatory factor 3 (IRF3) is the most crucial transcriptional mediator of cell-mediated expression of type I interferons Factor, its transcriptional activity and biological function directly affect the ability of antiviral cells.In recent years, significant progress has been made in the research of IRF3-related cell signal transduction and regulation mechanism etc. Focusing on the structure, function and molecular regulation mechanism of IRF3, Summarize the related research progress, and make forward-looking prospects.