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目的:探讨一期内外联合固定结合早期穿支血管蒂皮瓣治疗GustiloⅢ型踝关节骨折脱位伴软组织缺损的疗效。方法:回顾性研究2014年5月至2017年7月本院收治的20例GustiloⅢ型踝关节骨折脱位伴软组织缺损患者资料，男14例，女6例；年龄18～58(40±9.7)岁；损伤分型：Gustilo ⅢA型5例，ⅢB型12例，ⅢC型3例；踝关节骨折AO分型：A型4例，B型7例，C型9例；创面大小4 cm×3 cm～20 cm×9 cm；所有患者均行一期内外联合固定＋二期穿支血管蒂皮瓣修复治疗。受伤至初次手术时间1～8(5.5±1.4)h；自受伤至二期创面覆盖时间为7～21(12±4.7)d。其中胫后动脉穿支蒂皮瓣11例，腓动脉穿支皮瓣5例，前踝上皮瓣1例，胫后动脉穿支皮瓣联合腓动脉穿支皮瓣3例。结果:本组20例肢体全部保肢成功，无截肢患者。9例患者出现浅表感染，无深部感染及骨髓炎发生。19例皮瓣全部成活，1例胫后动脉穿支皮瓣远端部分坏死，后期植皮治愈。所有患者均获得随访，时间6～18(12±2.9)个月，皮瓣愈合良好，无窦道及骨外露发生，皮瓣感觉恢复，其中S1级2例，S2级12例，S3级6例。骨折愈合时间4～10(6.5±1.7)个月，无患者出现骨不连。按美国足踝外科评分系统评定疗效：优4例，良11例，可3例，差2例，优良率75%。结论:一期内外联合固定结合早期穿支血管蒂皮瓣治疗GustiloⅢ型踝关节骨折脱位伴软组织缺损可缩短治疗周期，早期功能锻炼，恢复肢体外观及功能，取得满意临床效果。“,”Objective:To investigate the clinical therapy of one-stage internal and external fixation combined with early perforator fiap for treatment of ankle fracture dislocation with soft tissue defects of Gustilo types Ⅲ.Methods:A retrospective study was conducted of the 20 patients with ankle fracture dislocation of Gustilo type Ⅲ who had been treated from May 2014 to July 2017 at Deparment of Traumatic Orthopaedics, the Second Hospital of Tangshan. There were 14 males and 6 famales among the patients, aged from 18 to 58 years (average, 40 years). There were 5 cases of Gustilo type ⅢA, 12 cases of type ⅢB, and 3 cases of type ⅢC; AO classification of ankle fractures: 4 cases of type A, 7 cases of type B, and 9 cases of type C; The wound size ranged from 4 cm×3 cm to 20 cm×9 cm. All patients were treated by primary internal and external fixation plus secondary transfer with a perforator flap. The times from injury to initial surgery ranged from 1 to 8 h (average, 5.5 h), the period from injury to secondary flap transfer ranged from 7 to 21days (average, 12 days). Among them, 11 cases of posterior tibial artery perforator flap, 5 cases of fibular artery perforator flap, 1 case of anterior ankle flap, and 3 cases of posterior tibial artery perforator flap combined with fibular artery perforator flap.Results:All 20 cases of limb preservation were successful, and there were no amputees. 9 patients showed superficial infection, no deep infection and osteomyelitis occurred. All 19 cases of flap survived, 1 case of distal part of posterior tibial artery perforator flap was necrosis, and the skin graft was cured later. All patients were followed up for 6 to 18 months (average, 12 months). The flap healed well. There was no sinus tract and bone exposure. The sensory recovery was S1 in 2 fiaps, S2 in 12 flaps, S3 in 6 flaps. The fracture healing time vanged from 4 to 10 months (average, 6.5 months), no bone disunion in patients. According to the American foot ankle surgery scoring system, the efficacy was assessed: 4 excellent cases, 11 good cases, 3 fair cases, 2 poor cases, yielding an excellent to good rate of 75%.Conclusions:One-stage internal and external fixation combined with early perforator fiap transfer is an effective strategy for treatment of ankle fracture dislocation with soft tissue defects of Gustilo types Ⅲ, due to its advantages of shortened treatment period, possibility for early rehabilitation, decreased complications and satisfactory functional recovery.