狼疮肾炎(LN)是系统性红斑狼疮(SLE)患者最严重的并发症和死亡的主要原因之一,几乎所有SLE患者在病程中均可出现肾脏损伤,达到一定程度可诊断为LN。活化正常T细胞表达和分泌的调节物(RANTES)由正常T细胞分泌和表达,在LN的免疫炎症形成、发展以及肾脏病理损害中起着重要作用,现就近年来RANTES与LN相关研究进行综述如下。 Lupus nephritis (LN) is one of the most serious complications and deaths in patients with systemic lupus erythematosus (SLE). Almost all SLE patients have kidney damage during the course of their disease, and can be diagnosed with LN to some extent. RANTES, which regulates the expression and secretion of normal T cells, is secreted and expressed by normal T cells and plays an important role in the formation and development of immune inflammation, as well as renal pathological damage in LN. The related researches on RANTES and LN in recent years are summarized as follows .