有关感染性休克发病机制及治疗的研究虽然有了一定的进展,但感染性休克尤其是革兰阴性菌(内毒素性)休克的发病率及病死率仍然很高。近年来有关鸦片样物质——内啡肽的研究以及内啡肽抑制剂——纳洛酮的临床应用已取得了一定的临床效果。此外,研究内毒素对细胞膜功能的影响也是发病机制研究的重点内容之一,从而对内毒素单克隆抗体的应用 Although some progress has been made in the pathogenesis and treatment of septic shock, the incidence and mortality of septic shock, especially Gram-negative bacilli (endotoxin) shock are still high. In recent years, the opioid - endorphin research and endorphin inhibitor - naloxone clinical application has achieved some clinical results. In addition, the study of the impact of endotoxin on the function of the cell membrane is also one of the key elements of the pathogenesis, and thus the application of endotoxin monoclonal antibody