血管内皮功能障碍是多种心血管疾病的共同病理生理基础,高血压、动脉粥样硬化(atherosclerosis,AS)、糖尿病等多种疾病均与血管内皮损伤及功能失调密切相关。近年来经皮腔内冠状动脉介入治疗(PCI)广泛用于冠心病的非药物治疗,而雷帕霉素洗脱支架能明显减少支架内再狭窄和临床不良事件发生率,多支、复杂病变患者亦从中获益。但研究发现[1-3],一些雷帕霉素洗脱支架植入术后的患者出现一 Endothelial dysfunction is the common pathophysiological basis of many cardiovascular diseases. Many diseases such as hypertension, atherosclerosis (AS), diabetes mellitus and other diseases are closely related to vascular endothelial injury and dysfunction. In recent years, percutaneous transluminal coronary intervention (PCI) is widely used in non-drug treatment of coronary heart disease, and rapamycin-eluting stent can significantly reduce the incidence of in-stent restenosis and clinical adverse events, multiple, complex lesions Patients also benefit from it. However, the study found that [1-3], some patients after rapamycin-eluting stent implantation appeared one