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立克次体是一类严格细胞内寄生的原核细胞型微生物,天然寄生于多种吸血节肢动物和昆虫体内,其生物学性状与细菌类似,已被列入生物战剂名录。立克次体病是由立克次体引起的一类人兽共患的自然疫源性疾病,可引起轻度乃至致命性疾病,给人类健康造成了极大威胁。立克次体专性细胞内寄生的生活方式决定其抗生素药敏试验方式与细菌传统方式不同。本文主要综述立克次体的药敏试验和立克次体病的治疗进展。
Rickettsia is a type of strict intracellular parasitic prokaryote-type microorganisms, naturally parasitic on a variety of blood-sucking arthropods and insects, and its biological properties similar to bacteria, has been included in the list of biological warfare agents. Rickettsial disease is a naturally occurring zoonotic disease caused by rickettsia that can cause mild and even fatal diseases, posing a great threat to human health. Rickettsia specific intracellular parasitic lifestyle determines its antibiotic susceptibility testing methods and bacteria different from the traditional way. This article reviews the Rickettsia susceptibility testing and rickettsial disease progression.