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目的本文主要是为了分析和探讨成人肾病综合征(NS)并发脑静脉窦血栓(CVST)的临床特点,从根本上达到诊疗水平不断提升的目的。方法选择2011年7月到2014年7月来我院接受治疗的89例成人肾病综合征并发脑静脉窦血栓的患者临床资料为研究对象,并对其临床特点、治疗措施、检查结果以及转归进行分析和研究,并通过头颅磁共振静脉血管成像的方法来对患脑静脉窦血栓形成进行观察和分析。结果患者的临床表现主要为呕吐、头痛、癫痫发作、运动功能障碍等。共有84例患者的MRV/MRL/CT诊断结果显示为患者的CVST为阳性,其余的5例患者因为接受MR诊断之后法却确诊,通过DSA检查之后,发现其病变部位主要表现为上矢状窦、横窦等。共有86例患者在检查过程中的血清白蛋白低于25g/L标准,经过系统的抗凝治疗之后,患者的D—二聚体以及FIB水平降低,患者的临床表现和治疗之前相比存在显著的差异。在对70例患者复查过程中进行头部MRV和MRI检查时发现共有62例患者显示为静脉窦或者静脉实现再通。经过系统的治疗之后,实现痊愈的共有80例,占患者总人数的89.9%,其m RS评分为0分,共有9例患者表现为遗留头痛,其m RS评分为1分,未出现任何患者的脑静脉血栓复发。结论肾病综合征患者出现运动功能障碍、头痛以及癫痫发作时,需要能够根据影像学检查结果来明确患者是否表现为CVST,对于并发静脉窦血栓的患者需要及早接受抗凝和诊断治疗,从而达到良好的预后效果。
Objective This article aims to analyze and discuss the clinical characteristics of adult nephrotic syndrome (NS) complicated with cerebral venous sinus thrombosis (CVST) and achieve the purpose of continuous improvement of diagnosis and treatment. Methods The clinical data of 89 patients with nephrotic syndrome complicated with cerebral venous sinus thrombosis treated in our hospital from July 2011 to July 2014 were selected as the research object and their clinical characteristics, treatment measures, test results and outcome Analysis and research, and by cerebral magnetic resonance venous angiography method of suffering from cerebral venous sinus thrombosis were observed and analyzed. Results The main clinical manifestations of patients with vomiting, headache, seizures, motor dysfunction. A total of 84 patients with MRV / MRL / CT diagnosis showed that patients with positive CVST, the remaining 5 patients because of the diagnosis of MR after the diagnosis, DSA examination found that the lesion mainly showed the superior sagittal sinus , Transverse sinus and so on. A total of 86 patients had serum albumin less than 25 g / L during the course of the study. D-dimer and FIB decreased after systemic anticoagulation, and the clinical presentation was significantly higher than before treatment The difference. A total of 62 patients showed recanalization of the sinus or venous vein during head MRV and MRI examinations of 70 patients. After systematic treatment, a total of 80 cases of complete recovery, accounting for 89.9% of the total number of patients, the m RSRS score was 0, a total of 9 patients showed residual headache, the m RS score of 1 points, no patients Recurrence of cerebral venous thrombosis. CONCLUSIONS: Nephrotic syndrome patients with motor dysfunction, headache, and seizures need to be able to ascertain whether a patient presents with CVST on the basis of imaging findings and who need early anticoagulation and diagnostic therapy for patients with sinus venous thrombosis to achieve good The prognosis.