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作者在为63例胃癌患者施行胃切除手术时,试行了一种防止癌转移的方法。即在开腹后,先在肿瘤原发灶周围浆膜下注射环磷酰胺500毫克或Neoc arzinostatin9毫克(药物需用20—50毫升液体稀释)。待间隔30—60分钟后,再开始进行胃切除术和淋巴结廓清术。作者测定切除淋巴结内的药物浓度,发现,术中局部注射抗癌药者,其所属淋巴结中药物之浓度为接受静注者的2倍。为了改善癌灶内的过凝固性和促进纤溶系统的功能,作者对部分患者,除术中给局注环磷酰胺外,尚在术前给予
The authors tried a method to prevent cancer metastasis when gastrectomy was performed on 63 patients with gastric cancer. That is, after laparotomy, cyclophosphamide 500 mg or Neoc arzinostatin 9 mg (diluted with 20-50 ml liquid) is injected subcutaneously around the primary tumor site. After a 30-60 minute interval, gastrectomy and lymphadenectomy are initiated. The authors determined the drug concentration in the resected lymph nodes and found that the intraoperative local injection of anticancer drugs was twice the concentration of the drug in the lymph nodes of the patients who received intravenous injections. In order to improve the hypercoagulability within the cancer foci and promote the function of the fibrinolytic system, the authors of these patients were given preoperatively, except for intraoperative cyclophosphamide injections.