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目的:检测人食管鳞癌组织中podoplanin的表达,分析其与患者临床病理特征及预后的关系。方法:采用免疫组织化学检测56例标本中podoplanin在癌细胞的表达水平以及计数癌组织中淋巴管密度。结果:正常食管鳞状上皮组织未见podoplanin表达,而食管鳞癌组织中可见podoplanin主要表达于食管癌细胞膜,其阳性率与淋巴结转移(P=0.042)、病理分期(P=0.025)及癌组织中淋巴管密度(P=0.036)相关。结论:Podoplanin不仅可以作为淋巴管内皮细胞特异性标志物评估癌组织的淋巴管生成外,也可表达于食管鳞癌细胞并与患者的临床病理参数相关。
Objective: To detect the expression of podoplanin in human esophageal squamous cell carcinoma and analyze its relationship with clinicopathological features and prognosis. Methods: Immunohistochemistry was used to detect the expression of podoplanin in 56 cancer samples and to count the lymphatic vessel density in cancer tissues. Results: The expression of podoplanin was not found in normal esophageal squamous epithelium. The expression of podoplanin in esophageal squamous cell carcinoma was significantly higher than that in esophageal cancer (P = 0.042), lymph node metastasis (P = 0.042) The lymphatic vessel density (P = 0.036) correlated. CONCLUSION: Podoplanin can not only be used as a specific marker of lymphatic endothelial cells to evaluate lymphangiogenesis in cancer tissues, but also be expressed in esophageal squamous cell carcinoma and correlate with clinicopathological parameters.