目的了解荆州市美沙酮门诊吸毒人员HIV、HCV的感染状况及其影响因素。方法对吸毒人员吸毒行为、肝功能有无异常、营养情况、并发症等进行问卷调查,并采血样检测HIV抗体、HCV抗体。结果 617名吸毒者中,HIV、HCV感染率分别为2.1%和70.5%。HCV感染与吸毒年限有关。男女吸毒人员吸毒行为比较:初吸毒年龄和吸毒年限差异有统计学意义(均P<0.01和P<0.05),但平均吸毒频次、平均吸毒量差异无统计学意义(均P>0.05)。女性吸毒人员中有并发症的比例(21.43%)高于男性吸毒人员中有并发症的比例(12.83%),差异有统计学意义(P<0.01)。营养状况不同吸毒人员的HCV感染无统计学差异(P>0.05),但营养状况不同吸毒人员肝功能和并发症的发生率差异有统计学意义(P<0.01)。用多因素logistic分析吸毒人员感染HCV的主要影响因素,其顺序为初吸年龄、吸毒量、肝功能、并发症、年龄。其中初吸年龄与HCV感染呈负相关。结论对吸毒人群中的高危行为应采取干预措施并在该人群中开展艾滋病知识的宣传教育工作。 Objective To understand the prevalence of HIV and HCV among drug addicts in methadone clinics in Jingzhou and its influencing factors. Methods Drug abuse behavior, liver function abnormalities, nutritional status, complications and other questionnaires were investigated, and blood samples were tested for HIV antibody and HCV antibody. Results Among 617 drug addicts, HIV and HCV infection rates were 2.1% and 70.5% respectively. HCV infection and drug-related years. The drug abuse behaviors of drug addicts between men and women were compared: the age of first addicts and the age of drug addicts were statistically significant (both P <0.01 and P <0.05), but the average frequency of drug abuse and the average drug addicts had no statistical significance (both P> 0.05). The proportion of complications among female drug users (21.43%) was higher than that of male drug users (12.83%), the difference was statistically significant (P <0.01). There was no significant difference in HCV infection among different drug users (P> 0.05). However, there was significant difference in the incidence of liver function and complications among different drug users (P <0.01). Multivariate logistic analysis of drug addicts infected with HCV main influencing factors, the order of initial smoking age, drug use, liver function, complications, age. Among them, the age of aspiration was negatively correlated with HCV infection. Conclusion Interventions should be taken on high-risk behavior among drug users and the publicity and education on AIDS knowledge should be carried out in this population.