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目的:探讨益气滋阴活血汤联合西药治疗冠心病的疗效及对CD40/CD40L表达的影响。方法:将在我院心内科就诊的84例冠心病患者随机纳入研究组和对照组各42例,研究组予益气滋阴活血汤联合阿托伐他汀钙胶囊,对照组单用阿托伐他汀钙胶囊,比较两组治疗效果及患者细胞CD40/CD40L表达的差异。结果:治疗有效率研究组高于对照组(P<0.01)。治疗后两组患者的全血高切黏度、全血低切黏度、浆比黏度和纤维蛋白原均较治疗前有所下降,且研究组各项指标较对照组下降更明显(P<0.01);治疗后研究组白细胞(WBC)、血小板(PLT)及WBC+PLT表达CD40和CD40L阳性细胞数均低于对照组(P<0.01)。结论:益气滋阴活血汤联合西药对冠心病具有较好的疗效,能明显降低患者CD40/CD40 L的表达。
Objective: To investigate the therapeutic effect of Yiqi Ziyin Huoxue Decoction combined with western medicine on coronary heart disease and its effect on the expression of CD40 / CD40L. Methods: Eighty-four patients with coronary heart disease in our department were enrolled in the study group and the control group, 42 cases in each group. The study group was given Yiqi Ziyinhuoxue Decoction combined with atorvastatin calcium capsule, the control group alone with atorvastatin Statin calcium capsules, the treatment effect and the difference of the expression of CD40 / CD40L between the two groups were compared. Results: The treatment efficiency in the study group was higher than that in the control group (P <0.01). After treatment, the two groups of patients with high blood viscosity, whole blood low shear viscosity, plasma viscosity and fibrinogen than before treatment decreased, and the study group indicators than the control group decreased more significantly (P <0.01) After treatment, the numbers of CD40 and CD40L positive cells in WBC, PLT and WBC + PLT group were lower than those in control group (P <0.01). Conclusion: Yiqi Ziyinhuoxue Decoction combined with Western medicine has good curative effect on coronary heart disease, and can significantly reduce the expression of CD40 / CD40 L in patients.