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具有多向分化潜能的骨髓基质干细胞(BMSCs)为力学敏感细胞,在体外适当机械刺激作用下,其生物学特性会发生功能性改变,以达到力学刺激的最佳要求,并表现为成骨向分化。此过程涉及多条信号转导通路,但BMSCs如何将机械刺激转变为生物信号,进而指导体内骨形成和改建的确切机制仍不清楚。本文就机械刺激对体外骨髓基质干细胞骨向分化的影响及可能的作用机制等方面的研究进展作一综述。
BMSCs with multipotential differentiation potential are mechanosensitive cells. Under appropriate mechanical stimulation in vitro, the biological characteristics of BMSCs will be functionalized to achieve the best requirements of mechanical stimulation. The bone marrow stromal cells Differentiation. This process involves multiple signal transduction pathways, but it remains unclear how BMSCs transform mechanical stimuli into biological signals that in turn guide the in vivo formation and remodeling of bone. This review summarizes the effects of mechanical stimulation on bone differentiation of bone marrow stromal cells in vitro and its possible mechanism.