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目的 :分析和探讨孕妇的血清β-绒毛膜促性腺激素 (β-h CG) ,妊娠特异性β1 糖蛋白 ( SP1 ) ,胎盘生乳素( h PL)三种激素在妊娠晚期应用于判断胎盘功能和了解胎儿预后的价值。方法 :放射免疫法测定孕妇血清 β-h CG,单向免疫扩散法测定 SP1 、h PL。结果 :中度及重度妊高征、低体重儿患者 β-h CG高值 ,SP1 和 h PL低值 ;轻度妊高征、羊水过少、羊水过多、巨大胎儿患者上述三者与正常妊娠组无显著差异。结论 :提示β-h CG与 SP1 和 h PL呈负相关 ,均可做为反映胎盘功能的指标 ,β-h CG升高、 SP1 、 h PL降低提示可能胎盘功能低下。非条件 logistic回归显示三者均为胎儿宫内窘迫的相关因素 ,二者或三者异常时患病概率高
OBJECTIVE: To analyze and explore the role of serum β-hCG, SP1 and SP1 in the third trimester of pregnancy to determine placental function And understand the value of fetal prognosis. Methods: Serum β-h CG of pregnant women was determined by radioimmunoassay. SP1 and h PL were determined by one-way immunodiffusion. Results: In patients with moderate and severe pregnancy-induced hypertension (PIH) and low birth weight, high β-h CG values, low values of SP1 and hPL, mild PIH, oligohydramnios and polyhydramnios, Pregnancy group no significant difference. CONCLUSION: The results suggest that β-h CG is negatively correlated with SP1 and hPL, both of which can be used as indicators of placental function. The increase of β-h CG and the decrease of SP1 and h PL may indicate the possible placental dysfunction. Non-conditional logistic regression showed that all three were related factors of fetal distress, and the high probability of abnormality when either or both were abnormal