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目的:探讨CD44smRNA在大肠癌细胞中表达的特点。方法:利用核酸原位杂交技术,对52例大肠癌组织进行检测。结果:CD44smRNA在大肠癌中总阳性率为65·38%(34/52)CD44smRNA表达与患者的性别、年龄及分化程度无相关性,而与有否淋巴结转移有一定的相关性。结论:CD44smRNA在大肠癌中有较高表达,可作为临床预测大肠癌转移潜能的一个重要参考指标。
Objective: To investigate the expression of CD44smRNA in colorectal cancer cells. Methods: Using nucleic acid in situ hybridization, 52 cases of colorectal cancer tissues were detected. Results: The overall positive rate of CD44 mRNA in colorectal cancer was 65.38% (34/52). There was no correlation between the expression of CD44 mRNA and sex, age and differentiation of patients, but with lymph node metastasis. Conclusion: CD44smRNA is highly expressed in colorectal cancer and may be used as an important reference for clinically predicting the metastatic potential of colorectal cancer.