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疟疾是全球三大传染病(艾滋病、疟疾、结核)之一.20世纪60年代以来,恶性疟原虫对原有的抗疟药如氯喹、Fansidar等逐渐产生抗药性,随着抗药性恶性疟的全球蔓延,全球疟疾发病率和病死率有增无减.2004年5月,世界卫生组织正式向各国推荐使用以青蒿类药物为基础的联合用药,这是被世界卫生组织评价为“目前世界范围内治疗恶性疟疾的唯一真正有效的药物”.1974年10月,在青蒿素对恶性疟的疗效尚不明确的情况下,全国抗疟研究办公室(“523”办公室)将
Malaria is one of the three major infectious diseases in the world (AIDS, malaria and tuberculosis). Since the 1960s, P. falciparum gradually developed resistance to the existing antimalarial drugs such as chloroquine and Fansidar. With the development of drug resistant falciparum Global spread, the global incidence of malaria and mortality increased unabated.In May 2004, the World Health Organization officially recommended to all countries to artemisinin-based combination therapy, which is evaluated by the World Health Organization as The only truly effective drug for the treatment of falciparum malaria worldwide. “In October 1974, while the efficacy of artemisinin against falciparum malaria was not clear, the National Malaria Research Office (” Office ")