用ＳＰ免疫组化法对１８６例患者良、恶性肿瘤组织中Ｐ￣（５３）蛋白的表达进行了检测，结果显示：恶性组阳性率为６１．３％，良性组阳性率为５．０％，二者之间染色阳性率的差异有高度显著性（ｐ＜０．０１），提示Ｐ￣（５３）基因异常与某些恶性肿瘤的发生有着密切的关系。 The expression of P ̄(53) protein in 186 patients with benign and malignant tumors was detected by SP immunohistochemical method. The results showed that the positive rate in the malignant group was 61.3% and the positive rate in the benign group was 5.0%. The difference in the positive rate of staining between the two was highly significant (p<0.01), suggesting that P53 gene abnormalities have a close relationship with the occurrence of certain malignant tumors.