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γ-干扰素(IFN-γ)和其它细胞素具有增进巨噬细胞抗菌作用,而已用于脓毒症的治疗。文内实验对巨噬细胞激活因子(γ-干扰素和白介素-4),及其单克隆抗体在调节急性感染反应中的作用进行了研究。将接受腹膜内注射内毒素(LPS)的345只雌性鼠随机分为5个治疗组,分别在注射LPS的同时或2小时后再接受γ-干扰素(INF-γ)、白介素-4(IL-4)、抗白介素-5单克隆抗体(抗-IL-5),抗-γ-干扰素单克隆抗体(抗-IFN-γ)或
Interferon gamma (IFN-γ) and other cytokines promote the antimicrobial activity of macrophages and have been used in the treatment of sepsis. In vivo experiments on the role of macrophage activating factor (γ-interferon and interleukin-4), and their monoclonal antibodies in the regulation of acute infection response were studied. A total of 345 female mice receiving intraperitoneal LPS were randomly divided into 5 treatment groups, and received either IFN-γ, IL-4 or IL-1 at the same time or two hours after LPS injection. -4), anti-interleukin-5 monoclonal antibody (anti-IL-5), anti-interferon gamma monoclonal antibody