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肌酸激酶(CK)被广泛用于Duchenne氏肌营养不良症(DMD)的监测和诊断,并认为是肌肉损伤最敏感的指标,而用于研究DMD的其他酶类(如烯醇化酶、醛缩酶、丙酮酸激酶和乳酸脱氢酶)没有一个是敏感的或特异的.在人的骨骼肌中碳酸酐酶Ⅲ(CA-Ⅲ)主要位于Ⅰ型纤维中,而CK位于Ⅱ型纤维中,因此,血清CA-Ⅲ的浓度反映Ⅰ型纤维的异常比CK敏感.作者用放射免疫法测定68例肌营养不良、10例DMD携带者和63例其他神经疾病病人血清CA-Ⅲ浓度,用活化N-乙酰半胱氨酸试剂盒分光
Creatine kinase (CK) is widely used in the monitoring and diagnosis of Duchenne’s muscular dystrophy (DMD) and is considered to be the most sensitive indicator of muscle damage whereas other enzymes used to study DMD (such as enolase, aldehydes No enzyme is pyruvate, pyruvate kinase and lactate dehydrogenase.) In human skeletal muscle, carbonic anhydrase III (CA-III) is predominantly located in type I fibers and CK is located in type II fibers , Therefore, the concentration of serum CA-III reflects the abnormality of type I fibers than CK.The authors used radioimmunoassay to determine the concentration of serum CA-III in 68 cases of muscular dystrophy, 10 cases of DMD carriers and 63 cases of other neurological diseases Activated N-acetylcysteine Kit Spectroscopy