基因序列数据正在以前所未有的速度迅速增长 ,建立新型杂交和测序方法以对大量的遗传信息进行高效、快速的分析、检测就显得格外重要。基因芯片技术就是在这种情况下应运而生的。基因芯片技术作为一种高通量的技术 ,是男性不育研究中的有力工具。本文综述了基因芯片技术在男性不育睾丸基因研究、精子mRNA分析、附睾基因研究、生殖毒理研究以及男性不育的诊断和治疗中的研究现状和临床应用前景。 Genetic sequence data is rapidly growing at an unprecedented rate. It is especially important to establish new hybridization and sequencing methods for efficient and rapid analysis of a large amount of genetic information. Gene chip technology is in this case came into being. Gene chip technology, as a high-throughput technique, is a powerful tool in the study of male infertility. This review summarizes the research status and clinical application of gene chip technology in the diagnosis and treatment of male infertility testis, sperm mRNA, epididymal genetics, reproductive toxicology and male infertility.