论文部分内容阅读
外阴阴道假丝酵母菌病(VVC)是妇女常见病及多发病,白假丝酵母(白色念珠菌)是其主要致病菌。我们通过在大鼠皮下注射大剂量雌激素建立大鼠的假发情模型,然后在大鼠阴道内接种白假丝酵母(白色念珠菌)SC5314悬液,建立大鼠的外阴阴道假丝酵母菌病模型。在不同时间点检测大鼠血浆中及阴道局部白细胞介素‐2(IL2)、甘露糖结合凝集素(MBL)、Toll样受体‐4(TLR4)的值,探讨VVC及复发性外阴阴道假丝酵母菌病(RVVC)的免疫发病机制。我们发现大鼠血清中只有TLR4在第2周出现显著性上升,而在阴道灌洗液中,IL2在第3周显著下降,TLR4在第2和第3周显著上升,MBL在第1至第3周均显著下降。由此我们推断在外阴阴道假丝酵母菌发病过程中,阴道局部免疫功能异常可能与VVC和RVVC的发生密切相关。
Vulvovaginal candidiasis (VVC) is a common disease and frequently-occurring disease in women, Candida albicans (Candida albicans) is the main pathogen. We established a rat model of pseudo-estrous by subcutaneous injection of large doses of estrogen in rats and then inoculated C. albicans SC5314 suspension into the vagina of rats to establish vulvovaginal candidiasis model. The levels of interleukin-2 (IL2), mannose-binding lectin (MBL) and toll-like receptor 4 (TLR4) in the plasma and vagina of rats were measured at different time points to investigate the relationship between VVC and recurrent vulvovaginism Silkworm Yeast disease (RVVC) immune pathogenesis. We found that only TLR4 in serum of rats showed a significant increase in the second week, while in vaginal lavage, IL2 decreased significantly in the third week, TLR4 significantly increased in the second and third weeks, MBL in the first to the 3 weeks were significantly decreased. Thus we infer that in the pathogenesis of vulvovaginal Candida, vaginal local immune dysfunction may be closely related with the occurrence of VVC and RVVC.