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目的 :探讨浸润性乳腺癌导管内扩散的形态特征及其与组织学分级、c erbB 2过表达及脉管累犯的关系。方法 :对 192例浸润性乳腺癌的导管内扩散情况及其与组织学分级、c erbB 2过表达及脉管累犯的关系进行统计分析。结果 :192例浸润性乳腺癌中 ,导管内扩散阳性 88例 (45 8% ) ;其中脉管累犯阳性组中 ,导管内扩散阳性率为 5 6 6 % ,明显高于脉管累犯阴性组(34 4 % ) ,且差异有显著性 (P <0 0 0 5 )。导管内扩散阳性组中 ,c erbB 2阳性率为 72 7% ,高于导管内扩散阴性组 (5 4 8% ) ,且差异有显著性 (P <0 0 2 5 )。导管内扩散与组织学分级呈正相关 (P <0 0 5 )。结论 :导管内扩散与组织学分级、c erbB 2过表达及脉管累犯呈现正相关 ,浸润性乳腺癌中伴导管内扩散者更具有侵袭性和转移性
Objective: To investigate the morphological characteristics of intraductal proliferation in invasive breast cancer and its relationship with histological grade, overexpression of c erbB 2 and recidivism. Methods: The intraductal proliferation of 192 invasive breast cancer and its relationship with histological grading, c erbB 2 overexpression and vascular recidivism were statistically analyzed. Results: Among 192 invasive breast cancers, 88 (45.8%) were positive for intraductal diffusion. Among them, the positive rate of intraductal diffusion was 56.6%, which was significantly higher than that of negative group 34 4%), and the difference was significant (P <0 0 0 5). The positive rate of c erbB 2 in the intraductal diffuse positive group was 72.7%, which was higher than that in the intraductal diffuse negative group (54.8%), and the difference was significant (P <0 025). Intraductal diffusion and histological grade was positively correlated (P <0 05). CONCLUSIONS: Diffusion in the duct is positively correlated with histological grade, overexpression of c erbB 2, and recidivism of the vessel. Invasive intraductal diffusers are more invasive and metastatic in invasive breast cancer